Table 2.
The major components associated with microfilarial destruction.
| NATURAL SITUATIONS | ||||
| DERMAL RESPONSES | ||||
| • | Clinical | |||
| Pruritus | ||||
| Self-destruction of the skin (mechanical) | ||||
| Development of dermal microabscesses | ||||
| • | Histopathological | |||
| Vascular endothelial activation | ||||
| Mast cell increase | ||||
| Blood and tissue eosinophilia | ||||
| Eosinophil adherence to the surface of the microfilariae | ||||
| Macrophage accumulation | ||||
| Fragmentation of microfilariae | ||||
| Local tissue damage (destruction of collagen, etc.) | ||||
| SYSTEMIC EFFECTS | ||||
| • | Antigen release | |||
| • | Organ dysfunction | |||
| • | Cytokine circulation | |||
| DRUG INDUCED SITUATIONS (additional activities): | ||||
| GENERAL (in addition to those activities in Natural Situations) | ||||
| • | Clinical | |||
| Migration of microfilariae | ||||
| Increased rate of Mf destruction, | ||||
| More rapid and severe development of the events | ||||
| Progressive movement of the papular response over different parts the body (with low dose DEC) | ||||
| • | Histopathological | |||
| Macrophage ingestion of excess eosinophil-derived material | ||||
| Evidence of immunostimulation | ||||