. Author manuscript; available in PMC: 2008 Dec 15.

Published in final edited form as: Bioorg Med Chem Lett. 2007 Oct 12;17(24):6879–6882. doi: 10.1016/j.bmcl.2007.10.015

Table 1.

Endothelial genes most distinctly regulated by TSS (100 μg/ml, 4 hours)

UniGene ID	Gene	Log ratio^a	Fold Change	Change^b	Change p-value^c
Hs.12813	TCDD-inducible poly(ADP-ribose) polymerase	0.7	1.6	I	0.00002
Hs.196384	Prostaglandin-endoperoxide synthase 2 (COX2)	1.0	2.0	I	0.00002
Hs.594481	Serpin peptidase inhibitor, clade B, member 2 (SerpinB2)	1.0	2.0	I	0.00002
Hs.433791	Transmembrane protein 46	0.9	1.9	I	0.00002
Hs.326035	Early growth response 1	0.8	1.7	I	0.00002
Hs.651231	Heparan sulfate proteoglycan 2 (perlecan)	−0.7	−1.6	D	0.99904
Hs.594486	Unknown	−1.9	−3.7	D	0.99944
Hs.29055	Guanine nucleotide binding protein-like 3	−0.8	−1.7	D	0.99955
Hs.557980	Unknown	−0.7	−1.6	D	0.99996
Hs.355753	1-acylglycerol-3-phosphate O-acyltransferase 6	−1.2	−2.3	D	0.99998

Log ratio: Log₂ (signal in TSS-treated HUVEC/signal in control HUVEC)

Change: Direction of change determined by Affymetrix Microarray Suite Version 5.0 (MAS5) Software

Change p-value: Log p-values are calculated using the Wilcoxon signed rank test and Tukey Biweight on MAS5. MAS5 calls a gene “decreased (D)” when its p-value between control and drug-treated groups is between 1 and 0.997, whereas a gene is considered “increased (I)” when its p-value is between 0 and 0.003. Shown on Table 1 are the top five up and down regulated genes based on the Change p-values.