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. 2007 Dec 20;118(1):40–50. doi: 10.1172/JCI33302

Figure 1. Phenotypic series of AM signaling–null mice.

Figure 1

Genetic deletion of genes responsible for AM signaling results in a phenotypic series of null mice with generalized edema and lethality at mid-gestation. (A) Generalized interstitial edema, without hemorrhage, was observed throughout calcrl–/– embryos at E12.5. Similar edema was present by E13.5 in AM–/–embryos (D) and by E14.5 in RAMP2–/– embryos (G). Edema was not observed 1 day before onset, and no viable embryos were recovered 1–2 days after edema onset. H&E-stained transverse sections of wild-type littermates (B, E, and H) and calcrl–/–, AM–/–, and RAMP2–/– (C, F, and I) embryos at E12.5, E13.5, and E14.5, respectively. Arrowheads indicate interstitial fluid accumulation. Original magnification, ×10 (A, D, and G); ×20 (B, C, E, F, H, and I).