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Iodine efflux assays of CFTR constructs stably transfected into human 293 cells. Samples were taken at 1-min intervals. Forskolin was added at the dashed vertical line. The slope of the initial increase in rate of loss was taken as an index of CFTR activity. The ΔF508 is a negative control. WT is the 4.7-kb wild-type CFTR cDNA, and S2 is the cDNA containing the entire coding sequence but with only a 30-bp untranslated region at the 5′-end.
