TABLE 6.

Conserved upstream regulatory region sequences shared between E(spl) genes

Sequence	HLHm3	m4	HLHm5	HLHm7	HLHm8	HLHmβ	HLHmγ	HLHmδ
E(spl) specific
ACGACAA	+		+
GGATCG	+					+	+
TTGTCGT	+		+
GTGAGAAA					+	+
ACGACAA	+		+
Shared with mesodermal enhancers (Espl specific)
GAAAGT					+		+	+
AAGTGT				+			+	+
GTGTGT (AGTGTGT)	+		+				+	+
ATTATC (ATTATCCT)			+		+	+	+
(CA)AATC(AT)	+					+	+
CAATAA	+		+		+	+	+
GATGTT	+					+
AATCGA	+	+
TCATCA	+				+
AGCAAT	+						+
CACAAT	+				+	+
ATTGCG	+		+			+
TAATTG	+	+	+		+	+
YCAATY
TGATAA			+			+	+
CACACG	+						+	+
AAATCT	+			+
AAAGTA	+		+		+
AGGCAC	+					+
ACACAC (ACACACT)	+	+	+				+
TTGCAG			+		+	+
AACAAT		+	+		+	+	+
Shared with neural enhancers
TTCTTGT			+	+		+	p	p
CACAATC	+				+
AATAACT			+	+
ACAAGA	+		+	+
AAGTAAA			+		+
TTTAATTG	p	+	p		p	p
TTTCAG	+				+	p	p
GATCGC	+					+	+
CACAATC	+				+	+
ATAAGGG				+			+
TCTTGT			+	+		+
TGCAGCT				+	+
TGATGAA	p		p	p	+
GAGGCA					+	+
GTGAGAA					+	+
TTTCAG	+				+
CACACGT	+	+						+
AAGGATC		+					+	+
CAGGATA		+			+
TTCTCAC		+			+		+	+
GCACGA						+		+
CACACGT	+	+	p	p			p	p

Underlined sequences refer to sites that are common to genes with overlapping expression patterns (as observed by Wech et al. 1999) during embryogenesis. + indicates conservation of sequence in nine species of Drosophila. p indicates partial conservation of consensus sequence in at least five species of Drosophila. Sequences in parentheses become E(spl) specific with additional flanking bases.