Figure 5.—

Neoplastic-like eye-disc phenotypes of MENE mutations. Phalloidin stains of complementation groups that show epithelial disorganization accompanied by upregulated actin polymerization and overgrowth. Overgrowth is mild with MENE (2L)-A (A) and MENE (3R)-B (E), intermediate with MENE (2L)-C (C) and MENE (3R)-A, and -D (D and G), and most dramatic with MENE (3R)-C (F) and MENE (3R)-E (H). MENE (2L)-B (B) is allelic to lgl, MENE (3R)-F (I) is allelic to scrib, and MENE (3R)-G (J) is allelic to warts. Bar, 100 μm.