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Lithiation vs. Grignard Manufacturing Issues for the Preparation of 3,4,5-Trichloro-2-thiophenecarboxylic Acid 23
| Route | Solvent | Reagent | Temperature (°C) | Yield 23 | Salt Waste |
| Lithiation | MTBE | n-BuLi | -60 | 92% | 1 eq Li salts |
| Grignard | THF | Mg,/1,2-DBE | 36 | 87%a | up to 2.7 eq Mg halide salts |
aSee text reference [28].
