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. 1998 Nov 2;143(3):673–685. doi: 10.1083/jcb.143.3.673

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Two alternative models for how Xklp2 and TPX2 could be localized to microtubule minus ends in a dynein dependent way. (A) Direct mechanism: Xklp2 and TPX2 interact with a dynein containing complex that moves towards the microtubule minus end or they bind directly to a component that has been transported there by dynein before. (B) Indirect mechanism: a protein that is transported to the minus ends by dynein creates a gradient along the microtubule (possibly by some enzymatic activity) that changes the affinity of TPX2 to Xklp2 and/or to microtubules.