Figure 1.

Kic1p kinase catalytic domain. (A) The Kic1p-kinase domain is aligned with its closest homologues: SOK1/Ysk1 (Pombo et al., 1996), CELT19A5 (Wilson et al., 1994), NIK1 (Su et al., 1997), MST1 (Creasy and Chernoff, 1995), PAK1 (Brown et al., 1996), and Ste20p (Leberer et al., 1992). The length in amino acids is indicated at the end of the bars. The percentage of identical residues with the Kic1p kinase domain is shown in the far right. (B) The NH₂-terminal amino acids of Kic1p are aligned with the catalytic domains of MST1 from H. sapiens, PAK1 from H. sapiens, and Ste20p from S. cerevisiae. Identical residues are indicated by the black boxes and amino acid number is indicated on the right. The 11 subdomains conserved in all kinases are indicated (Hanks et al., 1988; Lindberg et al., 1992). A short domain of additional homology is marked by asterisks above and below the text.