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. 1998 Nov 2;143(3):827–836. doi: 10.1083/jcb.143.3.827

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Compound BB-3130 inhibits islet morphogenesis without affecting cell differentiation. The rudiments were grown for 7 d in the absence (control) or in the presence of BB-3103 (1 μM or 10 μM). Adding 1 μM or 10 μM of compound BB-3103 inhibits islet morphogenesis (compare A to B and C). On the other hand, immunohistochemical analysis revealed that differentiation into insulin-positive cells in green or into glucagon-positive cells in red occured both in the absence (D) or in the presence (E and F) of inhibitor. The differentiation into amylase-positive cells did also occur in the absence (G) or in the presence (H and I) of BB-3103.