Table I.
List of Plasmids Encoding Inhibitors of Protein Kinases and Protein Phosphatases and Summary of Their Effects on Hormone-induced Melanosome Movement
Encoded protein | Plasmid | Melatonin (aggregation) | MSH (dispersion) | PMA (dispersion) | Melatonin + PMA | |||||
---|---|---|---|---|---|---|---|---|---|---|
PKA inhibitor, active | pNP210 | +* | −‡ | ± § | ± | |||||
PKA inhibitor, inactive | pNP211 | + | + | + | + | |||||
PKC inhibitor, active | pNP212 | + | + | + | − | |||||
PKC inhibitor, inactive | pNP214 | + | + | + | + | |||||
CAMKII inhibitor, active | pNP215 | + | + | + | + | |||||
CAMKII inhibitor, inactive | pNP216 | + | + | + | + | |||||
small t (PP2A inhibitor) | pCEP4-Sm t | − | + | |||||||
PP1 inhibitor | pNP231 | + | + | |||||||
PP2B inhibitor | pNP241 | + | + | |||||||
GFP | pEGFP-C1 | + | + | |||||||
PP2A | pGRE5-2 (T) 36 | + | − |
Dispersion or aggregation occurs normally.
No dispersion or aggregation.
Dispersion is partially inhibited.