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. 1998 Aug 10;142(3):763–774. doi: 10.1083/jcb.142.3.763

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Model for the ZW10/ROD-dependent targeting of dynein to the kinetochore. In this model, a complex containing ZW10 and ROD proteins, as well as potential unknown additional components (?), is associated with the fibrous corona of the prometaphase kinetochore. Direct interactions between ZW10 and the p50 subunit of the dynactin complex then bring dynactin to the kinetochore. Dynactin in turn recruits cytoplasmic dynein to the kinetochore, providing one possible contact between the kinetochore and microtubules. Our results suggest that this contact is sensitive to bipolar tension exerted across the chromosome. As described in the Introduction, additional kinetochore/microtubule interactions are undoubtedly mediated by other microtubule motors such as CENP-E (data not shown). This figure is modified from Vallee et al. (1995).