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. 1999 Mar 8;144(5):857–868. doi: 10.1083/jcb.144.5.857

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Bradykinin-induced elevation of cytoplasmic Ca²⁺ concentration is inhibited in crt ^−/− cells. Wild-type and crt ^−/− mouse embryonic fibroblasts (MEF) were loaded with the fluorescent Ca²⁺ indicator fura-2. Cells were stimulated with 1 μM thapsigargin, a Ca²⁺-ATPase inhibitor (A), or with 200 nM bradykinin (B). Solid line shows wild-type mouse embryonic fibroblasts and the dotted line shows calreticulin (CRT)-deficient mouse embryonic fibroblasts.