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. 1999 Mar 8;144(5):857–868. doi: 10.1083/jcb.144.5.857

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A model for the proposed role of calreticulin in the regulation of cardiac development. Myogenic signal from extracellular space activates the production of IP₃ that results in the release of Ca²⁺ from ER under the regulation of calreticulin (CRT). Increased intracellular Ca²⁺ binds to calmodulin (CaM) and activates calcineurin (CaN). CaN dephosphorylates NF-AT that translocates to the nucleus. In the nucleus NF-AT forms complexes with the GATA-4 transcription factors leading to activation of transcription of genes essential for cardiac development (Molkentin et al., 1998).