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. 1999 Mar 8;144(5):1019–1031. doi: 10.1083/jcb.144.5.1019

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(a) Constitutive hyperphosphorylation of FAK and paxillin in PTP-PEST (−/−) cells. Left column shows extent of tyrosine phosphorylation of immunoprecipitates as detected by the 4G10 antiphosphotyrosine mAb; right column shows evaluation of the amount of protein loaded using the same antibody as the immunoprecipitation. (b) Rescue of p130^CAS hyperphosphorylation in PTP-PEST (−/−) overexpressing wild-type PTP-PEST. p130^CAS was already shown to be a substrate for PTP-PEST (Garton et al., 1996) and to be hyperphosphorylated in the PEST (−/−) cells (Côté et al., 1998). Left panel shows phosphorylation levels of p130^CAS in each cell line; right panel shows loading control.