Fig. 6.

LGD5552 has less impact on bone formation and percentage of body fat than a steroid. Three-month-old male Swiss–Webster mice were treated orally with prednisolone or LGD5552 for 4 weeks. Treatment groups consisted of vehicle, prednisolone (3, 10, and 30 mg/kg), and LGD5552 (3, 10, and 30 mg/kg). Prednisolone (gray bars) raises the percentage of body fat at both 10 and 30 mg/kg, whereas LGD5552 (white bars) does not. Bone formation rate is significantly suppressed by prednisolone at all doses tested, whereas LGD5552 (white bars) suppresses at 30 mg/kg. LGD5552 is not significantly different from vehicle at 3 and 10 mg/kg.