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. 2007 Nov 28;104(49):19273–19278. doi: 10.1073/pnas.0708714104

Fig. 3.

Fig. 3.

HPLC quantitation of RPE lipofuscin pigments in eyecups of Abcr−/− and Abcr+/+ mice and in Abcr−/− mice genotyped for Rpe65 Leu450Met. Levels of A2E and isoA2E (measured separately and summed, A2E/isoA2E), atRALdi-PE, and total atRAL dimer series (atRAL dimer-phosphatidylethanolamine, atRAL dimer-E, and atRAL dimer measured separately and summed) plotted as a function of age. Detection was at 430 nm (A2E, atRALdi) or 500 nm (atRAL di-PE, atRALdi-E). Mice were homozygous for Rpe65 Leu-450 (L/L) or Rpe65 Met-450 (M/M). Each data point is from a single sample, with two to six eyes per sample.