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. 2007 Nov 28;104(49):19273–19278. doi: 10.1073/pnas.0708714104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 5. — Detection of photooxidized products of the RPE lipofuscin pigment atRAL dimer (atRALdi) in extracts of Abcr^−/− mouse eyecups. (Lower) Chromatographic overlay of HPLC profiles generated with samples of atRALdi plus endoperoxide of 1,4-dimethylnaphthalene (red), atRALdi plus MCPBA (blue), or extract of Abcr^−/− posterior eyecups (Rpe65 Leu-450; age, 12 months). (Upper) UV-visible absorbance of atRALdi and oxidized products of atRALdi. bP-atRALdi, bisperoxy-atRALdi; bF-atRALdi, bisfurano-atRALdi; mP-atRALdi, monoperoxy-atRALdi; mF-atRALdi, monofurano-atRALdi. a, cis-isomers of A2E; b, atRAL dimer-E; c, atRAL dimer-PE.