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Effects of long-term denervation on skeletal fibers ultrastructure. (A and B) Disarrangement of the internal structure of fibers starts from the periphery and results in complete disruption of the internal organization. (C) Shown is an area with misoriented contractile filaments. (D) Shown is an abnormal SR/T tubule junction. Filled stars, extracellular space; open arrows, mitochondria grouping; small filled arrows, fragmented SR; large filled arrows, Z lines; SM, surface membrane.
