Fig. 1.

LA blocks blastocyst implantation and reduces STAT3 phosphorylation in uterine luminal epithelium. Representative photomicrographs of uterus collected on D6.5 from mated mice treated with LA (7 mg/kg per day) by i.p. injection (A), s.c. injection (B), Alzet miniosmotic pump (C), i.p. injection plus miniosmotic pump (D) or with PBS by i.p. injection plus miniosmotic pump (control) (E). Arrows indicate implantation sites. (F and G) P-STAT3 immunostaining in mouse uterus on D3.5, 2 h after intrauterine injection of LA (1 mg/kg) (F) or PBS (G). The arrow shows positive nuclear staining in the uterine luminal epithelium. (Scale bars: A–E, 5 mm; F and G, 10 μm.)