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. 2007 Nov 27;104(49):19357–19362. doi: 10.1073/pnas.0710110104

Fig. 3.

Fig. 3.

PEGLA blocks blastocyst implantation and immunolocalizes to uterine luminal epithelium on D3.5. Shown are representative photomicrographs of uteri collected on D6.5 from mated mice treated with 12.5 mg/kg (25 μl) i.p. PEGLA (A) or control (mPEG2-NHS) (B) at 1200 hours and 2200 hours on D2.5 and 1000 hours on D3.5. Arrows indicate implantation sites. (C) H&E-stained cross section of A. (D) H&E-stained cross section of implantation site in B. (E) Higher magnification of C showing normal (intact) epithelial and stromal architecture after PEGLA administration. (F and G) PEG immunostaining in uteri of two different mice on D3.5 after i.p. administration of 12.5 mg/kg (25 μl) PEGLA at 1200 hours and 2200 hours on D2.5 and 1000 hours on D3.5. Arrows indicate positive staining as described in Results. (DS, decidualized stroma; IS, implantation site; LE, luminal epithelium. (Scale bars: A and B, 5 mm; C and D, 0.5 mm; E–G, 50 μm.)