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PEGLA was not lethal to preimplantation embryos. Shown are representative photomicrographs of preimplantation embryos collected on D3.5 from mice treated with PEGLA (A and B) or control (mPEG2-NHS) (C and D). Mated mice were administered 12.5 mg/kg (25 μl) PEGLA or control i.p. at 1200 hours and 2200 hours on D2.5 and 1000 hours on D3.5. (A and C) Morulae. (B and D) Blastocysts. (Magnification: ×400.)
