Table 3.

PEGLA is not lethal to preimplantation embryos

In vivo treatment	n	Morulae (%)	Unhatched blastocysts (%)	Hatched, attached, and outgrowing blastocysts (%)
PEGLA	5	16/32 (50)	5/32 (16)	11/32 (34)
Control	4	14/35 (40)	7/35 (20)	14/35 (40)

Mice were superovulated and mated, and PEGLA or control (mPEG2-NHS) was administered by i.p. injection (12.5 mg/kg) at 1200 hours and 2200 hours on D2.5 and 1000 hours on D3.5. Uteri were flushed, and embryos were collected on D3.5 and scored after 72 h of ex vivo culture.