Table 3.
In vivo treatment | n | Morulae (%) | Unhatched blastocysts (%) | Hatched, attached, and outgrowing blastocysts (%) |
---|---|---|---|---|
PEGLA | 5 | 16/32 (50) | 5/32 (16) | 11/32 (34) |
Control | 4 | 14/35 (40) | 7/35 (20) | 14/35 (40) |
Mice were superovulated and mated, and PEGLA or control (mPEG2-NHS) was administered by i.p. injection (12.5 mg/kg) at 1200 hours and 2200 hours on D2.5 and 1000 hours on D3.5. Uteri were flushed, and embryos were collected on D3.5 and scored after 72 h of ex vivo culture.