Comparison of the HRE consensus sequences and CACACAG/C elements in proximal intron 1 of human, rat, and mouse IGFBP-1 genes and select hypoxia-regulated genes. Nucleotide numbers are those used in GenBank sequences [human (37), rat (42), mouse (43)]. The putative HREs are shown in uppercase letters and are encased by a box. LDH, lactate dehydrogenase; PGK, phosphoglycerokinase.