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. 2007 Nov 27;104(49):19416–19421. doi: 10.1073/pnas.0707442104

Fig. 4.

Fig. 4.

The majority of MeCP2-bound promoters genome-wide are expressed genes. Comparison of the strongest MeCP2-bound promoters with genes expressed in differentiated SH-SY5Y neurons is shown. (Center) Shown is a Venn diagram of 1,524 MeCP2 promoter hits with 11,247 expressed genes (blue circle), which reveals that 954 or 62.6% of MeCP2-bound promoters are transcriptionally active genes. (Left) The strongest MeCP2-bound promoters were identified by comparing the top 2,600 bound promoters, removing duplicate promoters to obtain 2,563 and 2,567 hits, respectively, for two replicate arrays, ChIP-1 and ChIP-2. (Right) Expression microarray analysis of 48-h-differentiated SH-SY5Y cells in three biologic replicates (arrays 1–3) (20) was reanalyzed using a determination of expressed genes by Affymetrix mismatch analysis to identify a conservative common set of 11,247 expressed genes in SH-SY5Y neurons.