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. 2007 Nov 26;104(49):19512–19517. doi: 10.1073/pnas.0709443104

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© 2007 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 3. — BCL-2-overexpressing KB cells whose endogenous MCL-1 confers resistance to ABT-737. (a) Stable overexpression of BCL-2 in KB cells. (b) Reduction of MCL-1 expression in KB/BCL-2 cells by MCL-1 siRNA. (c) MCL-1 knockdown confers sensitivity to ABT-737 in KB/BCL-2 cells. KB/BCL-2 cells were transfected with human MCL-1 siRNA or luciferase (Luc) siRNA and plated into media containing 0.5 μM ABT-737. After 72, the percentage of cells incorporating annexin V FITC and propidium iodide was determined by flow cytometry.