sod-1(tm776) and ctl-1(ok1242) oxidative stress metabotypes and biological relevance. (a) The PLS-DA scores plot shows a discrimation among the three strains. (b and c) Summaries of O-PLS loadings between sod-1(tm776) and N2, ctl-1(ok1242) and N2, and sod-1(tm776) and ctl-1(ok1242), respectively (c), show variations in concentration that can be linked to metabolites by the use of 2D HRMAS COSY (and other 2D HRMAS correlation experiments) for assignment (b). Yellow squares, positive correlation; blue squares, negative correlation (where the first strain mentioned is the negative control and the second strain is the positive control). (d) Biochemical mechanisms of oxidative stress observed in sod-1(tm776) and ctl-1(ok1242) strains.