Fig. 3.

DAT fiber density in the striatum. (A–C) At 90 days, there was no difference in the amount of striatal DAT-positive fibers for saline-treated DAT-Cre (A), Ret^lx (B), and DAT-Ret^lx/lx (C) mice. (D–F) At 90 days after MPTP treatment, DAT staining was reduced in DAT-Ret^lx/lx mice (F) but partially recovered in DAT-Cre (D) and Ret^lx mice (E). (Scale bar, 25 μm.) (G and H) The bar graphs summarize the data for the dorsal (G) and ventral (H) striatum from three to four mice per group at 90 days after vehicle or MPTP treatment. Numbers are means ± SD. ***, P < 0.0001 compared with MPTP-treated DAT-Cre or Ret^lx mice; ANOVA followed by Tukey's post hoc test.