Table 1.
Stereological counts for TH-positive and Nissl-positive cells in the SNpc
| Genotype and treatment | TH+ neurons |
Nissl+ cells |
||
|---|---|---|---|---|
| 14 days | 90 days | 14 days | 90 days | |
| DAT-Retlx/lx | ||||
| NaCl | 8,580 ± 460 | 9,390 ± 448 | 11,940 ± 1,029 | 13,300 ± 1,157 |
| MPTP | 4,350 ± 266 | 4,394 ± 1466 | 6,700 ± 359 | 6,366 ± 1,241 |
| Retlx | ||||
| NaCl | 9,650 ± 556 | 8,940 ± 794 | 13,640 ± 1,021 | 13,010 ± 1,374 |
| MPTP | 4,390 ± 938 | 5,634 ± 686 | 7,570 ± 562 | 8,173 ± 1,208 |
| DAT-Cre | ||||
| NaCl | 9,130 ± 942 | 9,220 ± 344 | 12,720 ± 1,780 | 12,870 ± 453 |
| MPTP | 4,256 ± 370 | 4,334 ± 242 | 6,563 ± 732 | 6,813 ± 580 |
Values represent means ± SD. The decrease of TH-positive and Nissl-positive cells after MPTP treatment is significant (P < 0.001; ANOVA followed by Tukey's post hoc test) for each genotype. However, there are no differences for the factors genotype and time.