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. 1998 Apr 20;141(2):539–551. doi: 10.1083/jcb.141.2.539

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Serum induces fibronectin assembly in a Rho-dependent manner. Exogenous FN was added to quiescent, serum-starved Swiss 3T3 fibroblasts for 24 h (A and B), or to cells that were stimulated with serum for 24 h in the absence (C and D) or presence of C3 transferase (E and F). Cells were stained for actin (A, C, and E) and FN (B, D, and F). Quiescent cells have poorly developed actin stress fibers (A), and there is little FN assembly (B). Stimulation with serum induces stress fibers (C) and FN fibril assembly (D). These effects of serum are blocked when cells are incubated with C3 (E and F). Bar, 20 μm.