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. 1998 Apr 20;141(2):309–319. doi: 10.1083/jcb.141.2.309

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Immunostaining of centromere proteins (yellow signals) in +/+ R1 and −/− R1-189N/H cell lines using anticentromere antibodies. Results for the +/− R1-26 cell line were similar to those for the +/+ cell line and are not shown. Uniform signals were observed in all the centromeres in both cell lines when stained with CREST, anti-Cenpc, and anti-CENP-E antibodies. Note differences in the intensity of anti-CENP-B staining on different chromosomes in the +/+ cell line, with some centromeres (arrows) showing little or no detectable signals. No Cenpb signal was seen on the centromeres of the −/− cell line, even after maximal enhancement of fluorescence signal (thus the paler background) using computer imaging facility.