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. 1998 Apr 20;141(2):309–319. doi: 10.1083/jcb.141.2.309

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Model depicting the role of CENP-B and its putative functional homolog CENP-Z. (a) A centromeric satellite DNA array, showing individual monomers containing either a CENP-B-box (red bar) or a CENP-Z-box motif (blue bar). (b) CENP-B proteins (red circles) bind to CENP-B-box motifs and undergo dimerization to cross-link the array into a more stable higher order configuration. This mode of organization is presumably found on chromosomes where CENP-B boxes are prevalent, including the human and mouse autosomes and X chromosomes. (c) In the absence of CENP-B-binding, a functionally related protein CENP-Z (blue circle) assumes the role of CENP-B to cross-link CENP-Z box–containing monomers. This mode of organization is suggested for the human and mouse Y chromosomes, various CENP-B box-poor centromeric subdomains, and the centromeres of African green monkey and Cenpb null mice.