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. Author manuscript; available in PMC: 2008 Sep 17.
Published in final edited form as: Vaccine. 2007 Jul 26;25(37-38):6755–6763. doi: 10.1016/j.vaccine.2007.06.066

Figure 1.

Figure 1

Panels A through H. There is evidence of a strong effect of route (ID vs. IM) on maximum severity of local reactions in the 7 days after vaccination. Panels 1A, 1B, 1C, 1D vs Panel 1E, 1F, 1G illustrate the local reactions, pain, erythema and swelling by day post vaccine and route. This formal comparison utilized the 7-day maximum of severity of all local reactions, dichotomizing it as none/mild versus moderate/severe, and adjusted for antigen dosage (p < 0.001, by an exact test of association between route and moderate or greater maximum severity, stratified by dosage). Panel 1H illustrates the maximum local reactogenicity by dose.