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. Author manuscript; available in PMC: 2008 Nov 2.
Published in final edited form as: J Mol Biol. 2007 Aug 21;373(4):941–953. doi: 10.1016/j.jmb.2007.08.027

Figure 5. Molecular interactions involving mutated residues in the affinity-matured VHH.

Figure 5

The carbon atoms of VHH are in green and those of RNaseA are in white. The nitrogen and oxygen atoms are in blue and red, respectively. (A) Interactions involving CDR1 residues. H-bonds are depicted with dashed lines. (B) Interactions involving triads of polar residues. (C) Interactions involving Q102R and interface water molecules (spheres in light blue). See the main text for more details.