Skip to main content
. 1998 Aug 18;95(17):10224–10228. doi: 10.1073/pnas.95.17.10224

Figure 5.

Figure 5

Schematic representation of plasminogen-mediated HA cleavage. (A) Plasminogen binds to a lysine at the carboxyl terminus of the WSN NA. Bound plasminogen is activated to plasmin by a plasminogen activator (most likely of cellular origin). Enzymatically active plasmin then cleaves HA0 into HA1 and HA2 subunits. (B) If NA does not contain a lysine at the carboxyl terminus or an oligosaccharide chain is present in the vicinity, plasminogen does not bind to the NA and HA0 remains uncleaved.