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. 1998 Aug 18;95(17):10235–10239. doi: 10.1073/pnas.95.17.10235

Figure 1.

Figure 1

BDNF enhances responsiveness to iontophoretically-applied glutamate or NMDA but not acetylcholine or AMPA. (A) Example traces of control response to glutamate iontophoresis (10-ms pulse; indicated by arrowhead) and response after 20 min of BDNF exposure. Holding potential was −40 mV. The iontophoresis pipette was located in the dendritic region of pyramidal cells. Traces in this and subsequent figures represent the average of five consecutive sweeps. (B) Time course of mean effect of BDNF on glutamate (■) or acetylcholine (▴) responsiveness (mean ± SEM). (C) Example traces of control response to NMDA iontophoresis and response after 20 min of BDNF exposure. (D) Example traces of control response to AMPA iontophoresis and response after 20 min of BDNF exposure. (E) Group data for effects of BDNF on responses to glutamate (P < 0.01; n = 7), NMDA (P < 0.05; n = 7 cells), AMPA (P > 0.4; n = 5), or acetylcholine (P > 0.4; n = 4).