Figure 1.

Zn²⁺ concentration– AcCho current response relation in oocytes expressing ^WTα₇ receptors. The peak currents evoked by AcCho (150 μM) coapplied with Zn²⁺, at the concentrations indicated in the abscissa were normalized to the response to AcCho alone. Data are mean ± SEM (10 oocytes, 3 donors). Data without bars, mean of 2–4 oocytes. (Inset) Sample currents elicited by 150 μM AcCho alone (horizontal, continuous bar) or together with Zn²⁺ (horizontal, dashed bar). First and last traces, control and recovery. Oocytes held at −80 mV and pretreated for 30 s with Zn²⁺ before applying AcCho plus Zn²⁺.