Figure 4.

Zn²⁺ dose–current response relationship in oocytes expressing ^L247Tα₇ receptors. Peak inward currents evoked by Zn²⁺ are expressed as percentage of the response to 10 nM Zn²⁺. Each point represents mean ± SEM of 4–16 values (24 oocytes, 3 donors). Holding potential was −60 mV. Note the currents elicited at low concentrations possibly from, at least partially, Zn²⁺ contamination of the oocyte Ringer. (Inset, Left) Zn²⁺ current activated in one oocyte at the concentration indicated and blocked by MLA (1 μM). (Inset, Right) Zn²⁺ currents activated in another oocyte by Zn² applied alone. Holding potential, −60 mV.