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. 1998 Sep 7;142(5):1371–1379. doi: 10.1083/jcb.142.5.1371

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SDF-1α–induced migration through ICAM-1–coated filters is LFA-1–dependent at a low, but not at a high SDF-1 concentration. Data are the percentages of cells that have migrated in 2 h through an ICAM-1–coated filter to the lower chamber of a Transwell, containing the indicated SDF-1 concentration. Shown is the effect of the M17/4 mAb against LFA-1, with the GoH3 mAb against the α6 integrin subunit as control. M17/4 blocks completely at 1 ng/ml SDF-1, but not at all at 100 ng/ml. At both concentrations, migration depends on pertussis toxin-sensitive G proteins, since TAM2D2 cells expressing high levels of the S1 catalytic subunit of pertussis toxin do not migrate at all. Data are averages ± SE of two experiments performed in duplicate.