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. 1998 Sep 7;142(5):1371–1379. doi: 10.1083/jcb.142.5.1371

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SDF-1a–induced migration through ICAM-1–coated filters requires ZAP-70 at a low, but not at a high SDF-1 concentration. (a) Migration of the DN22 and DN38 cells expressing dominant-negative ZAP-70, parental TAM2D2 cells, and cells overexpressing wild-type ZAP-70 (WT). In contrast to TAM2D2 and WT cells, DN22 and DN38 cells do not migrate at all at 1 ng/ml SDF-1. At 100 ng/ml SDF-1, all cells migrate to the same extent. (b) Migration of TAM2D2 cells is blocked completely by piceatannol. Data are averages ± SE of two experiments performed in duplicate.