Abstract
The cytotoxic effect of the radiosensitizer misonidazole on hypoxic tumour cells in vivo has been studied. Using standard procedures of large single doses of X-ray (30 Gy) followed by 1.0 mg/g misonidazole, no significant cytotoxicity (measured by tumour regrowth) could be observed. In contrast, when utilizing post radiation hypoxia (3 h of 7% oxygen breathing) in conjunction with post radiation misonidazole, an increased amount of direct drug toxicity was demonstrated. The use of this acute hypoxia treatment may prove to be a useful tool for measuring various in vivo radiobiological responses.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fowler J. F., Adams G. E., Denekamp J. Radiosensitizers of hypoxic cells in solid tumors. Cancer Treat Rev. 1976 Dec;3(4):227–256. doi: 10.1016/s0305-7372(76)80012-6. [DOI] [PubMed] [Google Scholar]
- Gray A. J., Dische S., Adams G. E., Flockhart I. R., Foster J. L. Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations. Clin Radiol. 1976 Apr;27(2):151–157. doi: 10.1016/s0009-9260(76)80137-7. [DOI] [PubMed] [Google Scholar]
- Hall E. J., Roizin-Towle L. Hypoxic sensitizers: radiobiological studies at the cellular level. Radiology. 1975 Nov;117(2):453–457. doi: 10.1148/117.2.453. [DOI] [PubMed] [Google Scholar]
- Phillips T. L., Wasserman T. H., JohnsonRJ, Gomer C. J., Lawrence G. A., Levine M. L., Sadee W., Penta J. S., Rubin D. J. The hypoxic cell sensitizer programme in the United States. Br J Cancer Suppl. 1978 Jun;3:276–280. [PMC free article] [PubMed] [Google Scholar]
- Suit H. D., Sedlacek R. S., Silobrcic V., Linggood R. M. Radiation therapy and Corynebacterium parvum in the treatment of murine tumors. Cancer. 1976 Jun;37(6):2573–2579. doi: 10.1002/1097-0142(197606)37:6<2573::aid-cncr2820370602>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Urtasun R. C., Band P., Chapman J. D., Rabin H. R., Wilson A. F., Fryer C. G. Clinical phase I study of the hypoxic cell radiosensitizer RO-07-0582, a 2-nitroimidazole derivative. Radiology. 1977 Mar;122(3):801–804. doi: 10.1148/122.3.801. [DOI] [PubMed] [Google Scholar]
- Whitmore G. F., Gulyas S., Varghese A. J. Sensitizing and toxicity properties of misonidazole and its derivatives. Br J Cancer Suppl. 1978 Jun;3:115–119. [PMC free article] [PubMed] [Google Scholar]