Figure 4.
Expression of caveolins 1 and 2 in DRG neurons. (A) Immunoblot analysis. Lysates were prepared from cultures of rat DRG neurons and divided into Triton-soluble (S) and Triton-insoluble (I) fractions. Caveolin-1 (pAb N-20) and caveolin-2 (mAb 65) specific antibody probes were then used to probe these cellular extracts by immunoblotting. Note that both caveolins 1 and 2 are expressed and behave as Triton-insoluble components. (B) RT-PCR analysis. Total RNA isolated from PC12 cells and DRG neurons was subjected to RT-PCR analysis by using primers directed against the known sequences of caveolins 1 and 2; NIH 3T3 cells served as a postitive control.