Skip to main content
. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: Adv Pharmacol. 2008;56:509–557. doi: 10.1016/S1054-3589(07)56016-3

FIGURE 1.

FIGURE 1

The HPV genome is a 7.9 kb double-stranded circular genome. The genome is controlled by a single keratin-dependent promoter element; the long control region (LCR; in blue). At the 3′ end of the LCR is the origin of replication (nucleotide position 1). E6, E7 (red), and E5 are viral oncogenes; E1 and E2 early genes encode replication proteins. The E4 ORF is actually expressed early and late in the viral life cycle. The late genes, L1 and L2, are the major and minor capsid genes, respectively. The viral protein functions are detailed in Table I.