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. 1999 Aug 9;146(3):673–682. doi: 10.1083/jcb.146.3.673

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Requirement of the IAP MMS domain for supramolecular complex formation. αvβ3 was isolated from OV10 cells expressing wild-type IAP, IAP/CD7, IAP/GPI, or IAP/MC2 using beads coated with the αvβ3 ligand Vn or the anti-β3 mAb 1A2. Samples were analyzed by SDS-PAGE and Western blotting using the β3 specific mAb 7G2, the IAP specific mAb B6H12, or rabbit antibodies specific for Gβ. mAb 131, specific for the cytoplasmic tail of IAP, was used to probe for IAP/MC2. Similar results were obtained using beads coated with the β3 ligand, RGDS (data not shown).