Table 14.
Studies of the effect of lithium on conditioned preference and aversion tests in rats.
| Species, strain | Lithium | Experimental design | Results | Reference |
|---|---|---|---|---|
| Rat, Holtzmann | 20 experimental drugs tested | Muricide | All ADs, stimulants, and antihistaminics inhibited muricide. Amygdala lesion inhibited muricide | (Horovitz et al., 1966) |
| Rat, LE | Li i.p. | Muricide | Decreased | (Krames et al., 1973) |
| Rat, LE | Li i.p. | CTA | Li induced CTA | (Berg and Baenninger, 1974) |
| Rat, LE | Li i.g. | Muricide | Decreased | (Berg and Baenninger, 1974) |
| Rat, SD | Li i.p. | Muricide | Low-dose: no effect; high dose decreased, but maybe toxic | (Rush and Mendels, 1975) |
| Mouse, Harlan | Li i.p. | Cricket killing | Decreased | (Lowe and O’Boyle, 1976) |
| Rat, W | Li IV | CPA | Li produced CPA | (Mucha et al., 1982) |
| Rat, W | DMI, chloroipramine, AMI, CPZ, DZP, s.c. | Muricide | All decreased muricide, but CPZ and DZP also showed sedation | (Shibata et al., 1984) |
| Rat, Hooded | Li i.p. | CPA | Li dose-dependently institutes CPA | (White and Carr, 1985) |
| Rat, W | Li s.c. | Muricide | Decreased | (Yamamoto et al., 1985) |
| Rat, SD | Li chow | CPP/CPA | Li abolished MOR-induced CPP, naloxone-induced CPA, but not d-AMP-induced CPP or U-69593-induced CPA | (Shippenberg and Herz, 1991) |
| Rat, SD | Li i.p. | CPA/CTA | Rats conditioned for CPA and CTA showed strong CTA, but not CPA | (Schalomon et al., 1994) |
| Rat, SD | Li i.p. | CPP | Li did not affect COC-induced place preference | (Shippenberg and Heidbreder, 1995) |
| Rat, W | Li i.p. | CPA | CPA induced | (Frisch et al., 1995) |
| Rat, Lister | Li i.p. | CPP | Li decreases reinforcing value of sucrose | (Perks and Clifton, 1997) |
Abbreviations: AMI: amitryptiline; COC: cocaine; CPA: conditioned place aversion; CPP: conditioned place preference; CPZ: chlorpromazine; CTA: conditioned taste aversion; d-AMP: dexamphetamine; DZP: diazepam; i.p.: intraperitoneally; IV: intravenously; LE: Long-Evans; MOR: morphine; s.c.: subcutaneously; SD: Sprague-Dawley; W: Wistar.
Column “Lithium” is administration route of lithium or alternate mood stabilizer, if noted.