Table 4.
Studies of the effect of lithium on stimulant-induced stereotyped behavior.
| Species, strain | Lithium | Experimental design | Effect on stereotyped behavior | Reference |
|---|---|---|---|---|
| Rat, W | Li s.c. | d-AMP for SB | No effect | (Wielosz, 1976) |
| Rat Rat, SD |
Li s.c. | d-AMP, l-AMP, m-AMP, APO, COC i.p. for SB | Decreased | (Flemenbaum, 1977) |
| Mouse, ddI | Li i.p. | m-AMP, i.p. for SB | Decreased | (Ozawa and Miyauchi, 1977) |
| Mouse, Swiss | Li i.p. | d-AMP i.p., for SB | No effect | (Borison et al., 1978) |
| Mouse, Swiss | Li water | APO s.c., for SB | Decreased | (Frances et al., 1981a) |
| Mouse, ddl, ddY | Li i.p. | m-AMP i.p. for SB | Increased | (Miyauchi et al., 1981) |
| Rat, SD | Li chow | PCP or d-AMP i.p., for SB | Increased PCP-induced SB; no effect on AMP-induced SB | (Fessler et al., 1982) |
| Rat, SD | Li chow | AMP i.p., for SB | Increased | (Rubin and Wooten, 1984) |
| Rat, W | CBZ i.p. | APO i.p., for SB | Increased | (Barros and Leite, 1986) |
| Mouse, C57BL/6J | Li i.p. | d-AMP i.p., for SB | No effect | (Gould et al., 2007) |
Abbreviations: APO: apomorphine; CBZ: carbamazepine; COC: cocaine; d-AMP: dexamphetamine; i.g.: intragastrically; i.p.: intraperitoneally; l-AMP: levoamphetamine; Li: lithium; OFT: open field test; PCP: phencyclidine; SB: stereotyped behavior; s.c.: subcutaneously; SD: Sprague-Dawley; W: Wistar.
Column “Lithium” is administration route of lithium or alternate mood stabilizer, if noted.