Table 7.
Studies reporting the effect of lithium on various rodent models of aggression.
| Species, strain | Lithium | Experimental design | Effect on aggression | Reference |
|---|---|---|---|---|
| Rat. SD | Li i.p. | Shock-induced | Decreased | (Sheard, 1970) |
| Rat, SD | Li i.p. | Shock-induced | Decreased | (Eichelman et al., 1973) |
| Mouse, ddI | Li i.p. | Induced by nialimide plus L-DOPA, or by clonidine | Increased | (Ozawa et al., 1975) |
| Rat, SD | MAOI and dibenzazepines, i.p. | Shock-induced | Increased | (Eichelman and Barchas, 1975) |
| Rat, WR | Li i.p. | Shock-induced alone, as well as potentiated by d-AMP or scopolamine, i.p. | Decreased | (Mukherjee and Pradhan, 1976) |
| Mouse, TO | Li i.p. | Resident intruder, maternal aggression, and locust killing | Decreased resident intruder. Other tests inconclusive | (Brain and Al-Maliki, 1979) |
| Rat, W | IMI, amitriptyline, mianserin, iprindole, i.p. | Shock-induced | Increased | (Mogilnicka and Przewlocka, 1981) |
| Rat, SD | Li water | Shock-induced | Decreased | (Prasad and Sheard, 1982) |
| Mouse, AB | Li, VPA, or CBZ in water | Isolation-induced | Li, CBZ decreased; VPA, CBZ: no change | (Oehler et al., 1985) |
Abbreviations: CBZ: carbamazepine; d-AMP: dexamphetamine; i.p.: intraperitoneally; Li: lithium; MAOI: monoamine oxidase inhibitor; SD: Sprague-Dawley; VPA: valproic acid; W: Wistar; WR: Walter Reed.
Column “Lithium” is administration route of lithium or alternate mood stabilizer, if noted.