. Author manuscript; available in PMC: 2007 Dec 20.

Published in final edited form as: Neurosci Biobehav Rev. 2007 Apr 13;31(6):932–962. doi: 10.1016/j.neubiorev.2007.04.002

Table 9.

Studies of the effect of lithium on reward behaviors in rodents.

Species, strain	Lithium	Experimental Design	Effect on reward behavior	Reference
Rat, SD	Li i.p.	ICSS	No effect	(Ramsey et al., 1972)
Rat, LE	Li or d-AMP, i.p.	ICSS	Li decreased; AMP increased	(Cassens and Mills, 1973)
Rat, SD	Li i.p.	ICSS	Decreased, then normalized	(Edelson et al., 1976)
Rat, SD	Li i.p.	Alcohol consumption	Lithium decreased alcohol consumption, but increased severity of withdrawal symptoms	(Ho and Tsai, 1976)
Rat, Holtzmann	Li water	Alcohol consumption	Li produced earlier onset of adjunctive consumption of alcohol and water	(Hines, 1986b)
Rat, Holtzmann	Li water	Alcohol consumption paired with inescapable footshock	Alcohol consumption not affected by foot shock, but increased in animals treated with lithium and foot shock	(Hines, 1989)
Rat, W	Li i.p.	ICSS	No effect	(Takigawa et al., 1994)
Rat, SD	Li i.p.	ICSS	Decreased	(Tomasiewicz et al., 2006)

Abbreviations: d-AMP: dexamphetamine; ICSS: intracerebral self-stimulation; i.p.: intraperitoneally; LE: Long-Evans; Li: lithium; SD: Sprague-Dawley; W: Wistar.

Column “Lithium” is administration route of lithium or alternate mood stabilizer, if noted.