Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2000 Dec 25;151(7):1537–1548. doi: 10.1083/jcb.151.7.1537

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Protection of facial motorneurons from axotomy-induced degeneration. (A) Representative Nissl-stained sections of axotomized mice. The ipsilateral section of the wt mouse shows loss of facial motorneurons compared with the contralateral section, whereas the facial motorneuron number of the synRas-TG mouse remains equal on both sides. Arrowheads indicate well-preserved motorneurons with nucleoli in lesioned synRas-TG mice. Bar, 50 μm. (B) The number of facial motorneurons per section. Facial motorneurons of one out of three sections were counted. The first section is determined by the appearance of the first counted facial motorneuron. For better visualization, the ipsilateral distribution curve was centered within the contralateral distribution curve. Determination of wt facial motorneuron numbers reveals severe axotomy-induced degeneration along the total ipsilateral nucleus length, which cannot be detected in the synRas-TG mice. (C) The number of counted facial motorneurons per nucleus. Facial motorneurons of one out of three sections were counted. Total numbers of facial motorneurons per nucleus were not extrapolated. Analysis of counted facial motorneuron numbers reveals full protection of facial motorneurons from axotomy-induced degeneration by the transgene.

Protection of facial motorneurons from axotomy-induced degeneration. (A) Representative Nissl-stained sections of axotomized mice. The ipsilateral section of the wt mouse shows loss of facial motorneurons compared with the contralateral section, whereas the facial motorneuron number of the synRas-TG mouse remains equal on both sides. Arrowheads indicate well-preserved motorneurons with nucleoli in lesioned synRas-TG mice. Bar, 50 μm. (B) The number of facial motorneurons per section. Facial motorneurons of one out of three sections were counted. The first section is determined by the appearance of the first counted facial motorneuron. For better visualization, the ipsilateral distribution curve was centered within the contralateral distribution curve. Determination of wt facial motorneuron numbers reveals severe axotomy-induced degeneration along the total ipsilateral nucleus length, which cannot be detected in the synRas-TG mice. (C) The number of counted facial motorneurons per nucleus. Facial motorneurons of one out of three sections were counted. Total numbers of facial motorneurons per nucleus were not extrapolated. Analysis of counted facial motorneuron numbers reveals full protection of facial motorneurons from axotomy-induced degeneration by the transgene.