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The asymmetric p38 activation is required for symmetric and synchronous cleavage in zebrafish. “X,” unknown factor(s) transported from the vegetal pole through the vegetal microtubule array. DD, dorsal determinants; and “Z,” putative signal(s) transported from the vegetal pole through the vegetal microtubule array that compete with p38. V, ventral side; D, dorsal side.
